Cannabidiols: Biology and Medicinal Effects

Biology and Medicinal Effects

Many plant extracts and components have shown scientific evidence of their therapeutic effects on the human body.

Cannabidiol, also known as CBD on, is one of them. As such, researchers have explored the marijuana plant and extracted cannabidiol to study its components and test it for different biological activities. Through critical analysis, CBD has shown interesting results.

Science Behind CBD

Cannabidiol is found in marijuana plants, together with around 80 other compounds. It’s different from THC, another compound found in the marijuana plant because it’s not psychoactive. This means it’s not capable of intoxicating users.

This is possible because CBD has little effect on the CB1 receptors of the human brain. On the other hand, THC stimulates this receptor, inducing euphoria in an individual.

Additionally, CBD attaches itself to specific cells’ receptors in the body, particularly in the brain. The first one is the CB1 receptor, to which CBD has a lower affinity. This receptor can be found in the glial cells or neurons.

Meanwhile, the second receptor is the CB2 receptor which is located primarily in the immune system.

Scientific Evidence

Several studies have been conducted regarding the therapeutic effects of CBD. Although further research is still needed to prove its potency, the research available shows promising results.

These studies were conducted using cell cultures and some on model organisms. Some of the effects observed in these studies include analgesic, antioxidant, anti-inflammatory, anti-tumor, and anti-anxiety effects.

CBD Properties


Clinical studies found that Nabiximols was effective for addressing several painful conditions, like arthritis and neuropathic pain. However, its effectiveness was linked to THC rather than CBD.

Therefore, there is no conclusive evidence yet to support that CBD alone helps reduce pain.


Several successful studies showed how CBD could decrease the amount of stress and anxiety in treated animals. Aside from animals, it has also been observed in humans who suffer from extreme stress and social anxiety.

Its anti-anxiety effects are thought to be linked to the body’s serotonin receptor, 1a. However, further research is still needed to explain how it works.


The effectiveness of CBD on seizures has been evident in several studies. Researchers observed alleviation of symptoms in the model organism.

In fact, three out of four studies have reported success. However, some of them failed to present accurate data analysis of the results.

For example, there were deficiencies in the frequency of the seizures, and the application of statistical analysis was lacking. Because of this, the results aren’t conclusive and cannot be strongly supported.


The studies conducted to observe the antipsychotic effects of CBD were on a small scale only. Patients were treated with CBD to know whether it has beneficial effects. However, due to the low number of samples, it wasn’t possible to tell whether CBD has antipsychotic effects or not.


CBD has shown many potential effects in other biological activities, including having an anti-tumor property. There have been trials conducted using cultured cells or model animals. The findings of these trials showed promising results.

For example, some of them had reduced tumor growth, reduced metastasis, and augmentation in cancer cells’ death. However, these have yet to be observed in human participants.

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